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coeliac disease
The following articles have the tag coeliac disease
Shared genetic risk found for Crohn’s and coeliac disease
RESEARCHERS have found four common genetic risk loci after a combined meta-analysis of genome-wide data for both Crohn’s disease and coeliac disease. Both of these diseases are complex genetic traits with multiple genetic and non-genetic risk factors. Scientists from the Netherlands, the US and Canada found two shared-risk loci that had previously been independently identified for each disease – the PTPN2 and IL18RAP – and a further two, TAGAP and PUS10i. At least one in 100 people in the Western world develops coeliac disease, Crohn’s disease being far less common. Previous studies have shown coeliac ...
Diagnosing coeliac disease
Q: A young man with recurrent gastrointestinal symptoms is concerned about coeliac disease. What initial tests would be appropriate? A: The appropriate first test for suspected coeliac disease (CD) is IgA tissue transglutaminase (tTG) antibody. This has the best overall sensitivity and specificity (>90%), although it may miss patients with IgA deficiency. For this reason, a serum IgA can be performed at initial testing, and one approach is to use a dual IgA and IgG tTG antibody test. The incidence of IgA deficiency varies with racial background: in Middle Eastern populations it ...