Ibuprofen triggers severe ‘blended’ allergic reaction: case
Graded drug provocation tests are the gold standard for diagnosing NSAID hypersensitivity, doctors say.
Doctors have highlighted a unique case of possible anaphylaxis to two structurally dissimilar NSAIDs in a 45-year-old woman who was exposed to ibuprofen and aspirin, despite no history of allergic reactions or adverse events.
The otherwise healthy patient was referred to allergy and immunologist specialists from ED, where she received IM adrenaline after developing acute-onset dyspnoea, swelling lips and generalised urticaria in response to ibuprofen.
